Nucleoside diphosphate kinase A (NME1)

Nucleoside diphosphate kinase A (NME1) is a multifunctional enzyme encoded by the NME1 gene, known primarily for its role in synthesizing nucleoside triphosphates other than ATP, using a phosphate transfer mechanism[1][2][5]. It acts as a metastasis suppressor in human cancers, particularly by inhibiting cell migration, proliferation, and promoting apoptotic pathways while supporting DNA repair and maintaining genomic stability[4][3]. NME1 has kinase, exonuclease, and transcriptional regulatory activities, playing essential roles in cellular signaling, nucleotide metabolism, and direct regulation of gene expression and DNA damage repair[2][4][3]. Reduced expression or mutation of NME1 is associated with incrased metastasis risk, especially in neuroblastoma and other cancers[2][1]. NME1 is highly conserved and participates in diverse cellular processes, making it a critical node in both cell homeostasis and pathogenesis.

Other names

NME/NM23 nucleoside diphosphate kinase 1NM23NDPKANDK ANM23-H1NDP kinase AGranzyme A-activated DNaseMetastasis inhibition factor nm23Tumor metastatic process-associated proteinAWDGAADNBNBSNDKAnon-metastatic cells 1 protein (NM23A) expressed inepididymis secretory sperm binding protein

Not applicable (no established direct-acting drugs). For biological action: suppression of metastasis via kinase activity, regulation of cell motility, phosphorylation of key pathway members, and supporting DNA repair[3][4].