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Target intelligence / Profile preview
Nucleoside hydrolase 36 kDa (NH36)
- Target
- NH36
- Molecular classification
- Enzyme, Hydrolase
01
Overview
NH36 is an essential enzyme unique to certain protozoan pathogens like Leishmania spp., where it plays a critical role in nucleotide salvage pathways necessary for survival. Its absence from mammalian hosts makes it an ideal candidate both for targeted drug development—using inhibitors like immucillins—and as an antigen source for effective vaccines such as those based on recombinant protein or domain constructs. Its structural characterization further aids rational drug design efforts aimed at combating parasitic diseases including visceral leishmaniasis.
- Other names
- NH36 kDaNucleoside hydrolase
02
Mechanism of action
Inhibition of nucleoside hydrolysis
03
Biological functions
Hydrolysis of nucleosidesPurine salvageDNA synthesis
04
Disease associations
LeishmaniasisMalariaInfection
05
Safety considerations
Potential for off-target effects (though minimized by absence in mammals)Drug resistance
06
Interacting drugs
Immucillins
1 more in the full profile.
07
Biomarkers
T-cell response (IFN-γ, TNF-α secretion)Granzyme B productionPBMC proliferation
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