Nucleosome assembly protein 1-like 1 (NAP1L1)

Nucleosome assembly protein 1-like 1 (NAP1L1) is a highly conserved **histone chaperone** essential for chromatin dynamics in eukaryotic cells. It mediates the nuclear import of core histones H2A-H2B, nucleosome assembly, and chromatin fluidity, thereby affecting DNA replication, repair, and global transcriptional activity[1][3]. NAP1L1 participates in both replication-coupled and replication-independent chromatin assembly and is also implicated in diverse protein interactions relevant to cell cycle, proliferation, and development. In the heart, NAP1L1 is upregulated following myocardial infarction and acts as a crucial regulator of cardiac fibrosis by promoting fibroblast proliferation and migration through stabilization of YAP1[2]. Overexpression of NAP1L1 is also noted in several cancer types and has prognostic value. No clinically approved drugs directly target NAP1L1, but its functions make it a theoretically viable target in oncology and cardiac fibrosis.

Other names

NRPhNRPNAP1NAP1LMGC8688MGC23410NAP-1-related proteinHSP22-like protein interacting protein

No approved drugs specifically targeting NAP1L1 are reported in the literature. NAP1L1 may indirectly modulate disease processes via histone regulation or by affecting protein ubiquitylation/proteasomal degradation pathways (e.g., Yes-associated protein 1/YAP1 in fibrosis)[2].