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Nucleosome assembly protein 1-like 3 (NAP1L3)
- Target
- NAP1L3
- Molecular classification
- Other (member of the nucleosome assembly protein family, not a receptor, enzyme, channel, transporter, nor transcription factor)
01
Overview
Nucleosome assembly protein 1-like 3 (NAP1L3) is a protein encoded by an intronless gene on the human X chromosome. It belongs to the nucleosome assembly protein (NAP) family, whose members are involved in chromatin assembly and organization by facilitating histone and nucleosome dynamics. NAP1L3 is closely mapped to regions associated with several X-linked cognitive disability syndromes, but its mechanistic contribution to such diseases remains unclear. There is no evidence of its function as a receptor, enzyme, transporter, or drug target. Its biological role is generally inferred to be related to nucleosome assembly and chromatin structure rather than direct signal transduction or metabolic activity
- Other names
- NAP1L3MB20NPL3Brain-specific protein MB20nucleosome assembly protein 1 like 3
02
Biological functions
Nucleosome assembly/chromatin organizationDNA packagingPotential role in haematopoietic stem cell biology
03
Disease associations
Linked genomically to regions associated with X-linked cognitive disability syndromes (association is genomic, pathogenic role not fully established)
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