Nucleotide-binding oligomerization domain-containing protein 2 (NOD2)

Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an intracellular pattern recognition receptor that detects bacterial peptidoglycan fragments, specifically muramyl dipeptide (MDP). Upon MDP binding, NOD2 oligomerizes, recruits RIPK2, and activates downstream pathways like NF-kappaB and MAPKs, leading to pro-inflammatory cytokine production. Mutations in NOD2 are associated with Crohn's disease and other inflammatory conditions, making it a therapeutic target for modulating the innate immune response.

Other names

CARD15IBD1Caspase recruitment domain-containing protein 15Inflammatory bowel disease protein 1NLR family CARD domain containing 2NOD-like receptor C2

NOD2 activators and inhibitors modulate the inflammatory response by targeting the NOD2 signaling pathway.