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nucleotide-binding oligomerization domain leucine rich repeat containing X1 (NLRX1)
- Target
- NLRX1
- Molecular classification
- Nod-like receptor (NLR), Pattern Recognition Receptor (PRR)
01
Overview
NLRX1 is a member of the NOD-like receptor (NLR) family and functions as a mitochondrial-associated negative regulator of innate immune responses. It modulates various signaling pathways, including MAVS/RIG-I, NF-kB, and ROS/JNK, influencing inflammation, autophagy, and apoptosis. It is implicated in infectious disease, autoimmunity, cancer, and metabolic disorders. Its precise functions and mechanisms are still under investigation, presenting challenges for therapeutic targeting.
- Other names
- NOD-like receptor X1NOD5NOD9CLR11.3
02
Mechanism of action
Modulation of innate immune signaling pathways (e.g., MAVS/RIG-I, NF-kB), regulation of autophagy and apoptosis, modulation of ROS production.
03
Biological functions
Immune regulationNegative regulation of innate immunityRegulation of autophagyRegulation of apoptosisRegulation of ROS productionRegulation of inflammation
04
Disease associations
Infectious diseaseAutoimmunityCancerMetabolic disordersNeuroinflammation
05
Safety considerations
Contradictory findings regarding cellular localization and mechanisms across different cell types and disease modelsPotential for off-target effects due to broad regulatory role in inflammation and cell death
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