Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Nucleus accumbens-associated protein 2 (NACC2)
- Target
- NACC2
- Molecular classification
- Transcription factor (DNA-binding transcription repressor, RNA polymerase II-specific), Histone modification (histone deacetylase binding activity), Protein homodimerization
01
Overview
Nucleus accumbens-associated protein 2 (NACC2) is a DNA-binding transcription repressor, functioning primarily through interaction with the NuRD (nucleosome remodeling and deacetylase) complex. By recruiting NuRD to the MDM2 promoter, NACC2 represses MDM2 transcription, which stabilizes the tumor suppressor p53/TP53 and modulates cell apoptosis in response to DNA damage. It has additional protein homodimerization and histone deacetylase binding activity. NACC2 is linked to some cancer types but currently has no direct drug interactions documented[1][5][6].
- Other names
- NACC2BTBD14A
02
Mechanism of action
Transcriptional repression via NuRD complex recruitment, downregulation of MDM2 and stabilization of p53/TP53
03
Biological functions
Negative regulation of transcription by RNA polymerase IIRecruitment of NuRD complex (chromatin remodeling)Stability of p53/TP53 (through MDM2 repression)Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damageProtein homodimerization and homooligomerization
04
Disease associations
Cancer (associated with appendix adenocarcinoma and congenital mesoblastic nephroma)Other (potential role via p53 pathway modulation)
Beyond the preview
Go deeper on Nucleus accumbens-associated protein 2 (NACC2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Nucleus accumbens-associated protein 2 (NACC2).