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Nucleus pulposus
- Molecular classification
- Other (tissue component; not classified as receptor, transporter, enzyme, ion channel, transcription factor, etc.)
01
Overview
The nucleus pulposus is the central, gelatinous portion of the intervertebral disc, surrounded by the anulus fibrosus and situated between adjacent vertebral bodies. Its primary function is to absorb axial loads and provide a cushion that maintains the height and flexibility of the spine[1][2][3][5]. Compositionally, it consists of proteoglycans, collagen fibers (type II), and water-rich extracellular matrix, transitioning to a more fibrous state with age[2][3]. It has no direct blood supply or innervation, receiving nutrition via diffusion[2][3]. Pathological changes, such as herniation, can lead to clinical symptoms, but it is not a molecular target for drugs.
- Other names
- Nucleus pulposus
02
Biological functions
Shock absorption within the spineLimited facilitation of vertebral movementContribution to spinal mechanical strength and flexibility
03
Disease associations
Herniation (nucleus pulposus herniation is involved in disc herniation and can lead to nerve impingement)Degeneration (degenerative disc disease, especially with aging)Back pain (as a result of degeneration or herniation)
04
Safety considerations
Surgical treatments of herniation may damage spinal structures or nerves.Degeneration increases risk of injury
05
Interacting drugs
There are no drugs that directly interact with the nucleus pulposus as a target; therapies typically address symptom relief or modulation of processes related to it (e.g., anti-inflammatory agents, surgical procedures).
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