Nudix hydrolase 10 (NUDT10)

Nudix hydrolase 10 (NUDT10) is a human enzyme encoded on chromosome X and belonging to the nudix hydrolase family. It is a phosphohydrolase that regulates the turnover of diphosphoinositol polyphosphates and cleaves a beta-phosphate from PP-InsP5, linking it to signal transduction and intracellular signaling. NUDT10 can also catalyze hydrolysis of dinucleoside oligophosphates, with preferred substrates including Ap6A and Ap5A, as well as 5-phosphoribose 1-diphosphate. The enzyme may play key roles in cell cycle regulation, as knockdown experiments have demonstrated it is essential for cancer cell survival. Disease associations include autoimmune polyendocrine syndrome type II and adrenal cortical hypofunction. Its molecular classification is an enzyme, specifically a nudix hydrolase, and it is considered a potential therapeutic target based on functional genomics and cancer cell viability. There are multiple alternative names and aliases used in the literature, reflecting its biochemical characteristics and family relationships. No approved drugs or established biomarkers are recognized for NUDT10, and clinical targeting faces the general challenges of enzyme family redundancy and systemic effects.

Other names

Diphosphoinositol polyphosphate phosphohydrolase 3-alphaDIPP3ADIPP3α (DIPP3-alpha)HDIPP3α (hDIPP3alpha)Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alphaDiadenosine hexaphosphate hydrolase (AMP-forming)Nucleoside diphosphate-linked moiety X motif 10APS2Nudix (nucleoside diphosphate linked moiety X)-type motif 10Nudix motif 10