Nudix hydrolase 17 (NUDT17)

Nudix hydrolase 17 (NUDT17) is an enzyme belonging to the Nudix hydrolase family, characterized by the presence of a highly conserved Nudix box sequence that provides cation binding and catalytic activity[1][2][3]. NUDT17 acts as a hydrolase, most likely functioning in the hydrolysis of nucleoside diphosphate derivatives, including NADH and NADP, and can act as a decapping enzyme for certain monomethylated capped RNAs in vitro[3]. It plays a role in NADH metabolic and catabolic processes, and is predicted to be localized to the peroxisome[3]. NUDT17 is implicated in the regulation of nucleotide pool sanitization and cellular redox state, but its specific biological and disease functions in humans remain largely uncharacterized and require further study[1][3]. Diseases associated with NUDT17 include alpha thalassemia-intellectual disability syndrome type 1, and it shares similarity with other family members like NUDT12[3].

Other names

NUDT17NUD17

Catalytic hydrolysis of capped RNA and nucleoside diphosphate derivatives