Nudix hydrolase 4 (NUDT4)

Nudix hydrolase 4 (NUDT4) is an enzyme that catalyzes the hydrolysis of the beta-phosphate from diphosphoinositol polyphosphates, such as diphosphoinositol pentakisphosphate (PP-InsP5) and diphosphoinositol tetrakisphosphate (PP-InsP4), which are high-energy signaling molecules involved in regulation of intracellular signaling and trafficking[1][5][6]. NUDT4 also acts on diadenosine polyphosphates (notably Ap6A and Ap5A) and can hydrolyze 5-phosphoribose 1-diphosphate, a glycolytic activator[1][5][6]. It is involved in pathways related to metabolic regulation, with proposed but not firmly established roles in cellular signaling cascades, and does not show major known disease associations or therapeutic interactions at present[1][3][6]. Multiple alternatively spliced isoforms exist, such as DIPP2alpha and DIPP2beta, but the main biochemical activity is hydrolysis of diphosphoinositol polyphosphates[1].

Other names

DIPP2DIPP2alphaDIPP2betaHDCMB47PKIAA0487Nudix (nucleoside diphosphate linked moiety X)-type motif 4Diphosphoinositol polyphosphate phosphohydrolase type 2Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2Diphosphoinositol polyphosphate phosphohydrolase 2