NUF2 component of NDC80 kinetochore complex (NUF2)

NUF2 is a **core component of the NDC80 kinetochore complex**, a heterotetramer consisting of NUF2, NDC80 (also known as Hec1), SPC24, and SPC25[1][6]. This complex is **essential for the physical connection between spindle microtubules and centromeric chromosomal DNA during mitosis**[2][3][6]. The NUF2 subunit, together with NDC80, forms a microtubule-binding module localized at kinetochores that ensures proper chromosome alignment, spindle checkpoint signaling, and the equal segregation of chromosomes to daughter cells[3][6][7]. Recent studies have broadened its known functions to include a regulatory role in **ribosome biogenesis** during interphase, linking kinetochore machinery to nucleolar activity and cellular protein synthesis[1]. Aberrant NUF2/NDC80 activity can result in chromosomal instability, a hallmark of cancer, making it a potential therapeutic target for anti-mitotic agents, though no approved drugs directly target this complex as of now[1].

Other names

NUF2Nuf2pNuclear filamentous 2

Not applicable for approved drugs; pharmacological mechanism would hypothetically involve disruption of kinetochore-microtubule attachment, leading to mitotic arrest and cell death (as targeted by experimental tool compounds or investigational agents in research)