NUPR2 pseudogene 1 (NUPR2P1)

NUPR2P1 is described as a pseudogene of the NUPR2 (Nuclear Protein 2, Transcriptional Regulator) locus. Pseudogenes are genetic loci that resemble protein-coding genes but generally lack the ability to encode functional proteins due to disruptive mutations, truncations, or lack of regulatory elements. However, as with other pseudogenes, some may be transcribed and can function as long non-coding RNAs (lncRNAs) and participate in gene regulatory processes. Most pseudogenes, including NUPR2P1, are not considered valid therapeutic targets, as they generally do not encode proteins or act as conventional druggable targets such as receptors or enzymes[5]. There is no direct evidence in publicly available databases or scientific literature that NUPR2P1 is implicated in major diseases, regulates a known biological pathway, or serves as a biomarker or drug target. The parental gene, NUPR2, is a protein-coding gene encoding a transcriptional regulator involved in cellular stress, cell cycle regulation, and tumor biology[1], but the pseudogene itself (NUPR2P1) does not share these functions. Pseudogenes generally act at the RNA level, if expressed, and may influence gene expression by various mechanisms such as acting as competing endogenous RNAs or affecting chromatin states, but this has not been specifically established for NUPR2P1[5][3]. Notes on correctness and classification: - There is no evidence that NUPR2P1 encodes a receptor, enzyme, transporter, or other conventional therapeutic target; it is a pseudogene[5]. - No functional or therapeutic relevance has been reported for NUPR2P1, and it is generally not included in drug discovery target catalogs. - Its inclusion as a "target" would likely be an error or misunderstanding. - If your use case requires only classical protein-coding drug targets or functionally validated non-coding RNAs, NUPR2P1 should be excluded or flagged as incorrect. Summary: NUPR2P1 is a pseudogene, not a protein-coding gene or therapeutic target. It is not considered a valid target for drug discovery and there is no evidence for any disease or functional associations specific to this locus[5][3].

Other names

NUPR2P1NUPR2 pseudogene