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Target intelligence / Profile preview
Nur77 nuclear receptor (NR4A1)
- Target
- NR4A1
- Molecular classification
- Nuclear hormone receptor, Transcription factor, NR4A subfamily
01
Overview
Nur77 (NR4A1) is a member of the nuclear hormone receptor superfamily and the NR4A subfamily. It functions as a transcription factor, regulating cell proliferation, apoptosis, inflammation, and other processes. Its activity is modulated by subcellular localization and interactions with other proteins. It has been implicated in cancer, inflammatory diseases, and cardiovascular disease, making it a potential therapeutic target.
- Other names
- TR3NGFI-BNAKOrphan nuclear receptor Nur77
02
Mechanism of action
Direct binding/transcriptional regulation at target gene promoters, protein-protein interactions affecting other signaling pathways (notably NFκB), Subcellular localization-dependent functional switching
03
Biological functions
Transcription regulationCell proliferationApoptosisInflammation modulationImmunometabolismAngiogenesisCell cycle control
04
Disease associations
CancerChronic inflammation diseases (e.g., IBD/MS/RA/sepsis)Cardiovascular diseaseKidney injury
05
Safety considerations
Dual role in cancer (oncogenic vs. pro-apoptotic)Potential for off-target effects with small molecule modulators
06
Interacting drugs
Celastrol
2 more in the full profile.
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