NUT family member 2G (NUTM2G)

NUT family member 2G (NUTM2G) encodes a nuclear protein found on chromosome 9 and serves as a fusion partner in certain high-grade sarcomas, such as MAD::NUT fusion sarcomas and endometrial stromal sarcomas. While its standalone molecular function is not well-characterized, its disease relevance is as a component of oncogenic gene fusions, particularly in rare cancers where it forms fusions with MXD4 (MXD4::NUTM2G) or similar proteins[1][4]. NUTM2G mutations are also associated with male infertility syndromes, including various forms of spermatogenic failure[3]. No direct pharmacological interventions targeting NUTM2G exist, and its utility is mainly as a molecular marker for specific sarcoma subtypes[1][3][4][5].

Other names

NUTM2GFAM22GNUTMGhNUTM2GQ5VZR2NUTM2Gp

Null