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"Nutritional support via macronutrient and micronutrient supplementation" is not a molecule, receptor, or defined biological target. Instead, it refers to the clinical or dietary practice of increasing intake of essential nutrients—including macronutrients (proteins, fats, carbohydrates) and micronutrients (vitamins, minerals)—to address or prevent nutrient deficiencies and promote health[5][7][10]. Macronutrients are required in large amounts and provide energy and structural components to the body, while micronutrients are required in small amounts but are essential for virtually all cellular functions, growth, metabolism, and disease prevention[3][9][10]. Supplementation may be used in cases where dietary intake is inadequate or specific medical conditions demand greater nutrient intake, but lacks specificity as a single therapeutic target or druggable entity. Deficiencies in micronutrients can cause a range of diseases and subclinical impairments; excess intake can lead to toxicity or metabolic imbalances[4][8]. This term does not refer to a single protein, gene, receptor, or enzyme, but rather a public health and clinical nutrition intervention category.
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