Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC)
- Target
- NRAC
- Molecular classification
- Other, Transmembrane protein, Plasma membrane protein
01
Overview
NRAC (C14orf180), also known as Nutritionally-regulated adipose and cardiac enriched protein homolog, is a predicted transmembrane protein mainly expressed in adipose tissue and heart. Expression is nutritionally regulated, decreasing during fasting and obesity, and is highly induced during adipocyte differentiation. Knockdown studies (in stem cell models) suggest a role in adipocyte lipid accumulation, implicating NRAC in metabolic regulation and possibly disease, although its precise molecular function remains poorly understood. There are no documented clinical drugs or validated biomarkers associated with NRAC, but its restricted tissue pattern and potential involvement in metabolism make it an emerging candidate for further research in metabolic and cardiovascular disorders.
- Other names
- NRACC14orf180C14orf77Chromosome 14 open reading frame 180
02
Mechanism of action
Not established. No drugs targeting NRAC have a described mechanism; the physiological role relates to membrane localization and metabolic regulation.
03
Biological functions
Adipocyte differentiationLipid storage regulationRegulation of metabolism, especially in adipose and cardiac tissuesCellular response to nutritional status
04
Disease associations
Metabolic disordersObesityCardiovascular diseaseOther (possible links to growth traits in livestock)
05
Safety considerations
Unknown
Beyond the preview
Go deeper on Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC).