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NYN domain and retroviral integrase containing (NYNRIN)
- Target
- NYNRIN
- Molecular classification
- Other (protein encoding gene with NYN domain, retroviral integrase-like domain; not a classical receptor, enzyme, channel, or transporter)
01
Overview
NYN domain and retroviral integrase containing (NYNRIN) is a protein-coding gene predicted to enable RNA endonuclease and mRNA binding activities, and suggested to participate in DNA integration, DNA synthesis during repair, and DNA-templated replication[1][3]. The protein includes a NYN domain, structurally similar to nucleic acid-processing enzymes, and a region resembling a retroviral integrase catalytic domain, likely the result of an ancient gene fusion event[7]. NYNRIN is expressed in diverse human tissues, implicated in regulation of trophoblast invasion (via epithelial-mesenchymal transition and extracellular matrix remodeling), and has been associated with certain rare genetic disorders (osteopathia striata with cranial sclerosis, hereditary Wilms' tumor)[1][5]. It is not currently recognized as a therapeutic drug target[1][3][5].
- Other names
- KIAA1305CGIN1Cousin of GIN1FLJ11811AA409373C80530mKIAA1305protein NYNRIN
02
Biological functions
RNA endonuclease activitymRNA bindingDNA integrationDNA synthesis involved in DNA repairDNA-templated DNA replicationRegulation of genes involved in epithelial-mesenchymal transition and extracellular matrix remodeling
03
Disease associations
Cancer (based on roles in cell invasion and gene regulation; not extensively characterized)Osteopathia striata with cranial sclerosisHereditary Wilms' tumor
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