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Target intelligence / Profile preview
O^6-methylguanine-DNA methyltransferase (MGMT)
- Target
- MGMT
- Molecular classification
- Enzyme, DNA Repair Enzyme
01
Overview
Methylguanine methyltransferase (MGMT) is an essential nuclear enzyme responsible for direct reversal repair of toxic/mutagenic O^6-methylguanine lesions on DNA—a process crucial both for maintaining genomic integrity under normal conditions and determining tumor sensitivity/resistance during chemotherapy with alkylating agents.
- Other names
- Methylguanine methyltransferase
02
Mechanism of action
Direct reversal of O^6-methylguanine lesions via alkyl group transfer to a cysteine residue.
03
Biological functions
DNA repairGenome stability
04
Disease associations
CancerDrug resistance
05
Safety considerations
High MGMT activity confers resistance to alkylating chemotherapies.Loss of functional MGMT increases susceptibility to mutations and carcinogenesis following exposure to alkylating agents.
06
Interacting drugs
Temozolomide
07
Biomarkers
MGMT promoter methylation status
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