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Target intelligence / Profile preview
O-acetyl-GD2 Ganglioside (OAcGD2)
- Target
- OAcGD2
- Molecular classification
- Glycosphingolipid, Ganglioside, Cell Surface Antigen
01
Overview
O-acetyl-GD2 ganglioside is a modified form of the GD2 ganglioside, characterized by an O-acetyl group added to the terminal sialic acid residue. It exhibits restricted expression in normal tissues but is highly expressed in several tumors, including neuroblastoma, melanoma, and breast cancer stem cells. OAcGD2 is a target for antibody-based therapies and CAR-T cell therapy due to its tumor-specific expression, offering a potentially improved safety profile compared to therapies targeting unmodified GD2.
- Other names
- 9-O-acetyl-GD2O-acetylated GD2
02
Mechanism of action
Antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), direct apoptosis induction
03
Biological functions
Cell adhesionTumor progressionCancer stem cell maintenance
04
Disease associations
NeuroblastomaMelanomaSarcomaGliomaBreast cancerCancer stemness
05
Safety considerations
Potential for off-tumor toxicity (though less than anti-GD2)Immunogenicity of therapeutic antibodies
06
Interacting drugs
mAb 8B6
1 more in the full profile.
07
Biomarkers
Cancer stem cell marker (breast cancer)Tumor-associated antigen
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