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O-acetylated GD2 ganglioside
- Molecular classification
- Glycosphingolipid, Ganglioside, Oncofetal antigen
01
Overview
O-acetylated GD2 ganglioside is a disialoganglioside derivative with an acetyl group attached to the sialic acid residue. It is an oncofetal antigen overexpressed in various neuroectoderm-derived tumors and some carcinomas, but with limited expression in normal adult tissues, making it a promising target for immunotherapy with monoclonal antibodies and CAR-T cells. CASD1 is the enzyme responsible for the acetylation.
- Other names
- OAcGD29-O-acetyl-GD27-O-acetyl-GD2
02
Mechanism of action
Monoclonal antibody binding to O-acetylated GD2; CAR-T cell targeting
03
Biological functions
Cell proliferationNeuronal developmentGrowth cone extensionTumor cell survival
04
Disease associations
NeuroblastomaMelanomaGliomaSarcomaBreast CancerCancer
05
Safety considerations
On-target, off-tumor toxicity due to expression in normal tissuesImmunogenicity of antibodiesCytokine release syndrome in CAR-T cell therapy
06
Biomarkers
O-acetylated GD2 expression level in tumor tissue
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