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Target intelligence / Profile preview
O Antigen-Polysaccharide of Klebsiella pneumoniae (OPS)
- Target
- OPS
- Molecular classification
- Polysaccharide, Lipopolysaccharide component, Glycan
01
Overview
The O antigen-polysaccharide (OPS) is a key component of the lipopolysaccharide (LPS) found on the outer membrane of Klebsiella pneumoniae. It consists of repeating carbohydrate subunits that vary significantly between strains, contributing to serotype diversity and immune evasion. The OPS is a major virulence factor, providing resistance to complement-mediated killing and promoting systemic spread. It is an important target for vaccine development and immunotherapy, with the goal of eliciting protective antibody responses against clinically relevant serotypes.
- Other names
- O-antigenKlebsiella pneumoniae LPS O-antigenO-polysaccharideK. pneumoniae O-antigen
02
Mechanism of action
Antibodies targeting the OPS can promote complement-mediated killing or opsonization, preventing bacterial adhesion and invasion. Vaccines can elicit protective antibody responses against specific serotypes.
03
Biological functions
Complement evasionSerum resistanceAdhesionBiofilm formationImmune modulation
04
Disease associations
Klebsiella pneumoniae infectionPneumoniaSepsisUrinary tract infectionLiver abscess
05
Safety considerations
Potential for serotype replacement following widespread vaccinationRisk of inducing autoimmune responses due to structural similarities with host glycans (rare)Challenges in developing broadly protective vaccines due to high antigenic diversity
06
Biomarkers
OPS serotype as a predictor of virulenceAntibody titers against specific OPS serotypes as a measure of vaccine efficacy
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