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Target intelligence / Profile preview
O-GlcNAcase (OGA)
- Target
- OGA
- Molecular classification
- Enzyme, Glycoside hydrolase, Hexosaminidase
01
Overview
O-GlcNAcase (OGA) is an enzyme responsible for the removal of O-linked β-N-acetylglucosamine (O-GlcNAc) from serine and threonine residues on proteins. It plays a crucial role in regulating cellular processes, including gene transcription, energy sensing, and stress response. Dysregulation of OGA has been linked to various diseases, including metabolic disorders, neurodegeneration, and cancer. OGA is a therapeutic target and inhibitors like thiamet-G are used to study its function.
- Other names
- Protein O-GlcNAcaseOgaMGEA5N-acetylglucosaminidase
02
Mechanism of action
Inhibition of O-GlcNAcase, leading to increased O-GlcNAcylation of proteins
03
Biological functions
Regulation of O-GlcNAcylationGlycoside hydrolysisTranscriptional regulationEnergy sensingStress response
04
Disease associations
Diabetes/metabolic syndromeNeurodegenerative diseaseCancerCardiovascular diseaseImmune dysfunctionsAging processes
05
Interacting drugs
Thiamet-G
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