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Target intelligence / Profile preview
O-linked N-acetylglucosamine hydrolase (OGA)
- Target
- OGA
- Molecular classification
- Enzyme, Glycoside Hydrolase
01
Overview
O-linked N-acetylglucosamine hydrolase (OGA) is an enzyme responsible for removing the monosaccharide modification *O*-linked β-N-acetylglucosamine (*O*-GlcNAc) from serine and threonine residues of nuclear, cytoplasmic, and mitochondrial proteins. This process is a key part of the dynamic post-translational modification cycle called *O*-GlcNAcylation. The balance between OGA and OGT (O-GlcNAc transferase) is crucial for normal cell function, and dysregulation has been linked to various diseases.
- Other names
- Protein O-GIcNAcaseGlycoside hydrolase family 84 memberO-GlcNAcase
02
Mechanism of action
Inhibition of O-GlcNAc hydrolysis
03
Biological functions
Regulation of transcriptionRegulation of translationProtein stability regulationStress responseCell cycle regulationProtein localizationEnzyme activity modulation
04
Disease associations
DiabetesNeurodegenerative diseaseAlzheimer’s diseaseCancerCardiovascular disorders
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