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Target intelligence / Profile preview
O-linked N-acetylglucosaminidase (OGA)
- Target
- OGA
- Molecular classification
- Enzyme, Glycoside hydrolase, Hexosaminidase
01
Overview
O-linked N-acetylglucosaminidase (OGA) is an enzyme that removes O-linked β-N-acetylglucosamine (O-GlcNAc) from serine and threonine residues on nuclear and cytoplasmic proteins. It functions in opposition to O-GlcNAc transferase (OGT), which adds O-GlcNAc. The cycling of O-GlcNAc regulates diverse cellular processes. OGA is a therapeutic target in cancer, neurodegenerative diseases, and metabolic disorders.
- Other names
- MGEA5GCANCOAT
02
Mechanism of action
Hydrolyzes O-GlcNAc from serine and threonine residues on proteins, thus reducing *O*-GlcNAcylation levels
03
Biological functions
Regulation of protein glycosylationNutrient sensingStress responseCell cycle regulationRegulation of gene transcriptionCell signaling
04
Disease associations
CancerNeurodegenerative diseaseCardiovascular diseaseMetabolic disorders
05
Interacting drugs
GlcNAcstatin
2 more in the full profile.
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