O-polysaccharide moiety of Pseudomonas aeruginosa serotype O11

The **O-polysaccharide moiety of Pseudomonas aeruginosa serotype O11** is the variable, immunodominant carbohydrate chain extending from the outer membrane lipopolysaccharide (LPS) of this Gram-negative opportunistic pathogen[1][2][3][5]. It consists of repeating oligosaccharide units unique to serotype O11, structurally characterized by [-3)-α-L-FucNAc-(1-3)-β-D-FucNAc-(1-2)-β-D-Glc-(1-] (where FucNAc is N-acetylfucosamine)[1]. This structure defines the serogroup and is a key target of host immune response, serving as a major determinant of serotype-specific virulence, immune recognition, and epidemiology. It is also the immunological basis for certain vaccine strategies, as its surface exposure and specificity make it a prime target for antibody-mediated protection. There are no direct small-molecule therapeutics targeting this moiety, but recombinant or vaccine candidates have been engineered to stimulate immunity against strains harboring this antigen[1].

Other names

O-antigen of Pseudomonas aeruginosa serotype O11O-specific antigen (OSA) of Pseudomonas aeruginosa O11B-band LPS O11O11 O-polysaccharide

Induction of a protective immune response (targeted by vaccines to stimulate host immunity)[1].