O-polysaccharide of lipopolysaccharide from Pseudomonas aeruginosa serotype O11 (O-antigen (O11) (not a formal abbreviation, but a common practical shorthand))

The O-polysaccharide (O-specific antigen) of the lipopolysaccharide from Pseudomonas aeruginosa serotype O11 is a linear chain of repeating oligosaccharide units, typically containing unique sugars such as N-acetylfucosamine (FucNAc) and glucose, covalently attached to the outer core of the LPS[4][5]. This structure extends outward from the bacterial surface, dictates immunospecificity, and contributes to major virulence properties, including serum resistance and stimulation of host immune responses[3][5][7]. The genetic locus controlling its biosynthesis is well characterized, and O11 is recognized for its relatively simple structure compared to some other serotypes[4]. It is a primary determinant in serotyping schemes and an important consideration in vaccine and diagnostic development. If more detail on exact chemical structure or genetic locus is required, O11's O-repeat backbone is [-3)-α-L-FucNAc-(1-3)-β-D-FucNAc-(1-2)-β-D-Glc-(1-][4][5]. This entity is a correct and relevant therapeutic target candidate and is not incorrectly specified.

Other names

O-specific antigen (O11)O-antigen (O11)B-band LPS (O11)O11 O-polysaccharidePseudomonas aeruginosa O11 LPSOSA (O-specific antigen)

Antibodies: bind to O-antigen, mediate opsonization and complement activation, neutralizing pathogen Phages: recognize and bind to O-antigen for infection Some small molecules/peptides: disrupt polysaccharide structure or block biosynthesis