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Target intelligence / Profile preview
O6-Alkylguanine-DNA Alkyltransferase (AGT)
- Target
- AGT
- Molecular classification
- Enzyme, DNA Repair Enzyme
01
Overview
O6-alkylguanine-DNA alkyltransferase (AGT), also known as O6-methylguanine-DNA methyltransferase (MGMT), is a DNA repair protein that removes alkyl groups from the O6 position of guanine in DNA. This direct reversal mechanism protects cells from the mutagenic, cytotoxic, and carcinogenic effects of alkylating agents. The enzyme acts through a "suicide" mechanism, where it is irreversibly inactivated after accepting an alkyl group. High levels of AGT can confer resistance to chemotherapy drugs, making it a target for therapeutic intervention.
- Other names
- O6-methylguanine-DNA methyltransferaseMGMT
02
Mechanism of action
Direct reversal of DNA alkylation damage; "suicide" mechanism involving alkyl group transfer to a cysteine residue and subsequent enzyme inactivation.
03
Biological functions
DNA repairGenome maintenanceProtection against alkylating agents
04
Disease associations
CancerDrug resistance
05
Safety considerations
Drug resistance (high AGT/MGMT levels)Potential for off-target effects with AGT/MGMT inhibitors
06
Interacting drugs
Chemotherapeutic alkylating agents (e.g., temozolomide, dacarbazine)
07
Biomarkers
MGMT promoter methylation status (predictive of response to alkylating agents)AGT/MGMT protein expression levels
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