Octopamine receptor OAMB (OAMB)

The **Octopamine receptor OAMB** (OAMB) is an invertebrate G protein-coupled receptor that functions as an alpha-adrenergic-like octopamine receptor, predominantly described in the fruit fly (*Drosophila melanogaster*) and other insects[5][8][2]. It is involved in mediating the effects of the neuromodulator octopamine, which is the invertebrate analog to norepinephrine in vertebrates. Activation of OAMB leads primarily to increased intracellular calcium, modulating various physiological responses such as muscle contraction, energy metabolism, synaptic plasticity, and behavior[7][8][10]. OAMB is a major regulator of exercise adaptation, stress response, and arousal in insects, and is increasingly a focus for insecticide development due to its role in vector behavior and physiology[6][9]. There is no homologous protein in mammals. If you intended a mammalian adrenergic receptor (e.g., "Alpha-1 adrenergic receptor"), this is a different, unrelated GPCR responsive to norepinephrine and epinephrine, not octopamine[4].

Other names

OAMBOctαROA receptor, alpha subtypeCG3856

**Agonists**: Increase intracellular Ca^(2+) via Gq protein signaling cascade (the canonical downstream effect of OAMB) **Antagonists/inhibitors**: Block octopamine-induced signaling, inhibit Ca^(2+) or cAMP responses