Ocular surface mucin layer and epithelial glycocalyx

The **ocular surface mucin layer and epithelial glycocalyx** are not a single molecule or receptor, but together they constitute a critical *biophysical and biochemical interface* between the ocular surface epithelial cells (mainly conjunctival and corneal) and the tear film[4][5][6][7]. - **Membrane-associated mucins** (notably MUC1, MUC4, and MUC16) are heavily glycosylated proteins expressed on the apical surface of ocular epithelial cells, forming a dense *glycocalyx* that provides a barrier against pathogens, reduces friction, and maintains surface wettability[4][7]. - **Secreted gel-forming mucins** (notably MUC5AC, produced by goblet cells) contribute to the tear film's muco-aqueous layer, trapping debris and pathogens, providing lubrication, and facilitating clearance of foreign material[1][2][3][4]. These mucins are central to ocular surface integrity, lubrication, and defense. Alterations in either mucin production or the epithelial glycocalyx are strongly linked to dry eye disease, allergy, and infection[1][2][4][6]. Both are essential therapeutic targets *indirectly* in ophthalmology, but are not a single, druggable receptor, enzyme, or discrete molecular target.

Other names

Ocular mucins layerOcular surface mucinsMucin layer of tear filmOcular epithelial glycocalyx

Indirect modulation of mucin gene expression and secretion; improvement of goblet cell function and epithelial health