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Ocular Surface Mucins (OSM)
- Target
- OSM
- Molecular classification
- Glycoprotein, Mucin, Secreted mucin, Membrane-associated mucin
01
Overview
Ocular surface mucins are a family of high-molecular-weight glycoproteins crucial for maintaining the health and function of the eye's surface. They are essential components of the tear film, providing lubrication, hydration, and protection. They are classified into secreted (gel-forming and soluble) and membrane-associated (cell surface) types, each with distinct but complementary roles in maintaining ocular surface homeostasis. Deficiencies or alterations in mucin expression are implicated in various ocular surface diseases, particularly dry eye disease.
- Other names
- Tear film mucinsCorneal mucinsConjunctival mucins
02
Mechanism of action
Stimulates mucin secretion; goblet cell protection.
03
Biological functions
Ocular surface lubricationTear film stabilizationEpithelial protectionPathogen trappingAnti-adhesionOsmosensingBarrier formation
04
Disease associations
Dry eye diseaseKeratoconjunctivitis siccaOcular surface inflammationInfectious keratitis
05
Safety considerations
Potential for allergic reactionsLimited long-term safety data for some mucin-stimulating drugs
06
Interacting drugs
Diquafosol
1 more in the full profile.
07
Biomarkers
MUC5AC levelsGoblet cell densityTear film breakup time
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