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Target intelligence / Profile preview
Ocular Vasculature
- Molecular classification
- Blood Vessels, Vasculature
01
Overview
The ocular vasculature refers to the network of blood vessels supplying the eye, particularly the retina and choroid. Diagnostic visualization of this vasculature is crucial for detecting, monitoring, and understanding a wide range of ocular diseases such as diabetic retinopathy, age-related macular degeneration, retinal vein occlusion, and other vascular pathologies. Key imaging modalities include Fluorescein Angiography (FA), Optical Coherence Tomography Angiography (OCTA), Confocal Scanning Laser Ophthalmoscopy (cSLO), and Spectral-Domain Optical Coherence Tomography (SD-OCT). These techniques are used to diagnose ischemic or neovascular conditions, monitor disease progression, and guide treatment decisions.
02
Mechanism of action
N/A (visualization target, not a drug target directly)
03
Biological functions
Oxygen transportNutrient deliveryWaste removalRegulation of blood flow
04
Disease associations
Diabetic RetinopathyAge-Related Macular DegenerationRetinal Vein OcclusionOcular Ischemic SyndromeGlaucoma (vascular component)
05
Safety considerations
Risk associated with fluorescein dye injection (FA)Motion artifacts in OCTALimited field of view in some OCTA devices
06
Interacting drugs
Anti-VEGF agents (e.g., Bevacizumab, Ranibizumab, Aflibercept)
2 more in the full profile.
07
Biomarkers
Foveal Avascular Zone (FAZ) areaVascular leakageNeovascularizationCentral Retinal Artery Equivalent (CRAE)Central Retinal Vein Equivalent (CRVE)
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