Odr-4 GPCR localization factor homolog (ODR4)

Odr-4 GPCR localization factor homolog (ODR4) is a protein-coding gene predicted to be involved in intracellular protein localization, specifically with a probable function in the trafficking and maturation of a subset of G protein-coupled receptors (GPCRs). ODR4 is an integral membrane protein located predominantly in the endoplasmic reticulum, where it can interact with other proteins such as alpha2A-adrenergic receptors, facilitating their correct localization and trafficking through the secretory pathway. It does not act as a receptor, enzyme, or transporter, but as a supporting factor important for ensuring the cell-surface delivery and functional expression of specific GPCRs. The human ODR4 gene (also known as C1orf27) is located on chromosome 1. There are no drugs directly targeting ODR4, and it is not considered a direct therapeutic target, biomarker, or known source of therapeutic safety concern. Disease association is suggested for Penicilliosis and Familial Glucocorticoid Deficiency but the direct mechanistic link remains uncharacterized.

Other names

C1orf27c2h1orf271810053E15RikBC003331MGC:7150