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OGFR antisense RNA 1 (non-protein coding) (OGFR-AS1)
- Target
- OGFR-AS1
- Molecular classification
- Long non-coding RNA, Antisense RNA, Non-coding RNA
01
Overview
OGFR-AS1 is a long non-coding RNA (lncRNA) transcribed from the antisense strand of the OGFR gene locus. Antisense lncRNAs such as OGFR-AS1 do not encode proteins but instead function at the RNA level to regulate gene expression through multiple mechanisms, including recruitment of chromatin modifiers, RNA-RNA interactions affecting splicing and stability, and transcriptional interference with their sense (protein-coding) partners. These antisense RNAs can modulate key biological processes such as cell proliferation, cell cycle, apoptosis, and differentiation, and their dysregulation has been linked to various diseases, most notably cancer. OGFR-AS1 has not been directly characterized as a therapeutic target or biomarker, but is part of the growing landscape of regulatory non-coding RNAs with potential roles in gene regulation and disease pathways[1][2].
- Other names
- OGFR-AS1OGFR antisense RNA 1 (non-protein coding)
02
Biological functions
Regulation of gene expressionChromatin remodelingEpigenetic regulationModulation of alternative splicingRegulation of mRNA stability
03
Disease associations
Cancer (overexpression or dysregulation of antisense lncRNAs is often implicated in various cancers and other diseases due to their regulatory role on sense genes)
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