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Target intelligence / Profile preview
Oil-in-Water Emulsion Adjuvant AS03 (AS03)
- Target
- AS03
- Molecular classification
- Adjuvant, Emulsion
01
Overview
AS03 is an oil-in-water emulsion adjuvant system used in vaccines to enhance immune responses. It is composed of squalene, α-tocopherol (vitamin E), and polysorbate 80. AS03 is designed to boost both the magnitude and quality of the immune response to vaccine antigens, allowing for antigen-sparing strategies and improved protection against infectious diseases. It activates multiple innate immune pathways, induces local inflammation, and enhances antigen uptake and presentation by APCs, ultimately leading to enhanced antibody and T cell responses.
- Other names
- Squalene + α-tocopherol + polysorbate 80 adjuvantAdjuvant System 03
02
Mechanism of action
Activates innate immunity; enhances adaptive antibody/memory B cell/T cell responses through local inflammation, ER stress, cytokine induction, and improved APC function
03
Biological functions
Innate immune activationAdaptive immune response enhancementCytokine production inductionAntigen presentation enhancementB cell maturationT cell activation
04
Disease associations
InfectionInfluenzaCOVID-19
05
Safety considerations
Local injection site reactionsTransient inflammatory response
06
Interacting drugs
Influenza vaccines (H1N1/H5N1)
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