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Target intelligence / Profile preview
Oleoyl-acyl-carrier-protein hydrolase (OLAH)
- Target
- OLAH
- Molecular classification
- Enzyme, Thioesterase, Hydrolase
01
Overview
Oleoyl-acyl-carrier-protein hydrolase (OLAH) is an enzyme that catalyzes the hydrolysis of oleoyl-[acyl-carrier-protein] to release free oleate and acyl carrier protein, functioning in the medium-chain fatty acid biosynthetic process[2][3][1][5]. It acts broadly on substrates with chain lengths between 10 and 16 carbons. OLAH is predicted to localize in the cytosol and enables fatty acyl-[ACP] hydrolase activity. The gene is associated with pathologies such as rheumatoid arthritis and other diseases, with roles in metabolic and fatty acyl-CoA biosynthesis pathways. OLAH is also referred to by synonyms including THEDC1 and AURA1, and its UniProt identifier is Q9NV23[3].
- Other names
- S-acyl fatty acid synthase thioesterase, medium chainTHEDC1AURA1TE2SASTFLJ11106Augmented in rheumatoid arthritis 1Thioesterase 2Thioesterase IIThioesterase domain-containing protein 1type II thioesteraseoleoyl-ACP hydrolase
02
Mechanism of action
no targeted drugs are reported; mechanism would hypothetically involve inhibition or modulation of fatty acid release if targeted
03
Biological functions
Fatty acid biosynthesisFatty acyl-[ACP] hydrolase activityRelease of free fatty acids from fatty acid synthase
04
Disease associations
Rheumatoid arthritisArthritisOther (evidence for additional disease associations from genetic and expression studies)
05
Biomarkers
Possibly elevated in rheumatoid arthritis (linked to alias "Augmented in rheumatoid arthritis 1")
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