Olfactomedin-like protein 1 (OLFML1)

Olfactomedin-like protein 1 (OLFML1) is a secreted glycoprotein of the olfactomedin family, encoded by the OLFML1 gene located on human chromosome 11p15.4[1][4]. It contains an olfactomedin domain and consists of 402 amino acids[1][4]. OLFML1 is highly expressed in non-neural tissues such as small intestine, liver, lung, heart, and spleen, and has minimal to no expression in the brain[1][4]. Its protein enhances human cancer cell proliferation *in vitro* through acceleration of the cell cycle S phase entry[1], and it is involved in osteoblast biology—specifically, it inhibits Hippo signaling and affects mineralization, thus contributing to bone development and potentially to diseases like congenital scoliosis via effects on osteoblast differentiation[3]. Although OLFML1 belongs to a protein family implicated in several pathological processes, its explicit physiological and pathological roles, as well as its therapeutic targeting potential, require further research[1][3][4].

Other names

Olfactomedin-like 1OLFML1ONT2UNQ564/PRO1126UNQ564MVAL564