Target intelligence / Profile preview

Olfactory receptor 1N2 (OR1N2)

Target
OR1N2
Molecular classification
G protein-coupled receptor, Receptor
01

Overview

Olfactory receptor 1N2 (OR1N2) is a member of the olfactory receptor family—a group of G protein-coupled receptors characterized by a seven-transmembrane domain structure, encoded by a single exon gene in humans[8][5]. OR1N2 is responsible for the initial molecular detection of odorant molecules in the olfactory epithelium of the nose, activating G protein-coupled signaling cascades that result in the perception of smell[8][5][7]. Like other olfactory receptors, OR1N2 participates in recognizing structurally diverse odorants, contributing to the broad chemosensory repertoire of the mammalian olfactory system[6][5]. The gene nomenclature for olfactory receptors in humans is species-specific and does not necessarily correspond across mammals[8]. While olfactory receptors in general can play roles in nonolfactory tissues and diseases, no specific disease relevance is currently attributed to OR1N2[3][5][8]. There are no drugs, biomarkers, or safety issues reported for this receptor.

Other names
Olfactory receptor family 1 subfamily N member 2Olfactory receptor OR9-23OR9-23
02

Mechanism of action

Not applicable for therapeutics (the biological mechanism is recognition and transduction of odorant molecules via G protein-mediated pathways)

03

Biological functions

Signal transductionSensory perception (smell)
04

Disease associations

Other (no strong direct evidence of roles in human disease, but olfactory receptor dysregulation may be implicated in certain nonolfactory physiological processes; general references exist for ORs in brain, pancreas, testes, with altered function sometimes observed in neoplasms or other conditions)
05

Safety considerations

None known (not considered a target for therapeutic development, so no known safety liability)
06

Interacting drugs

None known (no drugs are currently known to selectively target OR1N2 or olfactory receptors generally as pharmacological agents)
07

Biomarkers

None established (no validated biomarkers for patient selection or monitoring involving OR1N2)

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