Olfactory receptor 2J2 (OR2J2)

Olfactory receptor 2J2 is a G protein-coupled receptor expressed in olfactory sensory neurons, characterized by a seven transmembrane domain structure. It interacts with specific odorant molecules in the nose—such as 1-Octanol, 1-Nonanol, and Coumarin—to initiate a neuronal response that triggers the perception of smell. This receptor is part of the largest gene family in the human genome and shares structural features with many neurotransmitter and hormone receptors. Its activation follows a canonical mechanism: ligand binding leads to G-protein signaling, production of second messengers, and ultimately neuronal depolarization. No significant disease associations or therapeutic uses are currently linked to OR2J2, and its biological role is primarily restricted to olfactory signal transduction.

Other names

ORL684DJ80I19.4OR6-8OR6-19HS6M1-6OR6.3.8

Agonists (odorant molecules) bind to OR2J2, activating intracellular G-protein signaling pathways that lead to transduction of chemical signals into neuronal activity