Olfactory receptor 2J3 (OR2J3)

Olfactory receptor 2J3 (OR2J3) is a member of the G protein-coupled receptor (GPCR) superfamily and specifically functions as an olfactory receptor in the human nose[1][3][4]. It is responsible for detecting specific odorant molecules, especially cis-3-hexen-1-ol, a compound with a characteristic "green, cut grass" smell released by wounded plants[1][2][3]. Variation in the OR2J3 gene affects individual sensitivity to this odorant, and certain variants (T113A and R226Q) can substantially reduce or abolish this sensory perception[2][3]. OR2J3 initiates signal transduction upon ligand binding by activating G proteins, leading to neuronal signals that are interpreted as distinct odors. While it is not a conventional drug target or disease-associated molecule, OR2J3 exemplifies how genetic variation in olfactory receptors impacts sensory perception and potentially dietary preferences in humans[2][3].

Other names

Olfactory receptor family 2 subfamily J member 3OR2J3OR6-6Olfactory receptor 6-6Hs6M1-3Olfactory receptor OR6-166M1-3C3HEXSHS6M1-3OR6-16OR6.3.6ORL671

Odorant binding activates G protein-mediated signal transduction, initiating sensory neuron activation and olfactory signal transmission[1][2][3].