Olfactory receptor 52E6 (OR52E6)

Olfactory receptor 52E6 (OR52E6) is a member of the olfactory receptor family, specifically family 52 subfamily E, expressed in Homo sapiens[5][7][8]. Like all olfactory receptors, OR52E6 is a G protein-coupled receptor (GPCR) characterized by a seven-transmembrane domain structure, and it mediates the recognition and G protein-dependent signal transduction of odorant molecules in the olfactory system[4][5][7][8]. OR52E6 is part of the largest gene family in the human genome and is involved in the detection of odorant compounds, triggering downstream neuronal pathways that contribute to the sense of smell[4][7]. While OR52E6 itself does not have well-documented pharmacological ligands or direct disease relevance outside olfactory function, the olfactory receptors as a group are essential for sensory perception of odors. OR52E6 is occasionally referenced in literature with the alias "Olfactory receptor OR11-58"[2][5][7]. Key structural features, like other olfactory receptors, include its origin from a single coding-exon gene and its placement among class A (rhodopsin-like) GPCRs[3][4][5][6][7]. Olfactory receptors, including OR52E6, can recognize a range of odorants but typically lack selectivity for classical drug-like ligands, and there are no clinically approved drugs that selectively target this receptor. There is no strong evidence for therapeutic targeting or biomarker use for OR52E6 at this time.

Other names

Olfactory receptor OR11-58OR11-58Olfactory receptor family 52 subfamily E member 6olfactory receptor 52E6olfactory receptor OR11-58