Target intelligence / Profile preview

Olfactory receptor 52E8 (OR52E8)

Target
OR52E8
Molecular classification
G protein-coupled receptor, Receptor, Olfactory receptor, 7-transmembrane protein
01

Overview

Olfactory receptor 52E8 (OR52E8) is a G protein-coupled receptor expressed primarily in the olfactory epithelium of the nose, where it is responsible for the detection of specific odorant molecules and the initiation of neuronal signals that result in the perception of smell[1][3][4]. Like other olfactory receptors, OR52E8 possesses a 7-transmembrane domain structure typical of class A GPCRs, arising from a single coding exon[3][4][7]. The olfactory receptor gene family, of which this gene is a member, is the largest in the human genome. OR52E8 is considered a functional gene and not a pseudogene[2], but it is not regarded as a pharmacological or therapeutic target. There is no evidence of clinically relevant drug interactions or established disease associations for this receptor.

Other names
OR11-54HsOR11.3.85ORL3334Olfactory receptor OR11-54Olfactory receptor family 52 subfamily E member 8
02

Biological functions

Signal transductionSmell perception (olfaction)G protein-mediated transduction of odorant signals
03

Disease associations

Other (No strong disease links; one association note with growth hormone secreting pituitary adenoma, not considered well-established or causal[3])

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