Target intelligence / Profile preview

Olfactory receptor 5W2 (OR5W2)

Target
OR5W2
Molecular classification
G protein-coupled receptor, Receptor, Olfactory receptor
01

Overview

Olfactory receptor 5W2 (OR5W2) is a G protein-coupled receptor predominantly expressed in the human olfactory epithelium, where it mediates the recognition of specific odorant molecules and initiates neuronal responses necessary for the perception of smell. Like other olfactory receptors, OR5W2 possesses a seven-transmembrane domain structure and is encoded by a single coding-exon gene[1][2][8]. These receptors represent the largest gene family in the human genome and operate via G protein-mediated pathways to transduce odorant signals[2][1][6]. While essential in sensory physiology, OR5W2 is not known to play a direct role in human disease and is not a therapeutic target or established biomarker in medical practice[6][2][8].

Other names
Olfactory receptor family 5 subfamily W member 2OR5W2POR5W3POlfactory receptor 5W3Olfactory receptor OR11-155olfactory receptor, family 5, subfamily W, member 3 pseudogene
02

Mechanism of action

not applicable (no drugs; physiological mechanism is odorant-induced activation of G protein signaling cascade)[2][1]

03

Biological functions

Signal transductionOdorant recognitionG protein-mediated olfactory signal transduction
04

Disease associations

Other (no specific disease associations reported; primarily sensory function)[6][2]
05

Safety considerations

none known (as a sensory receptor not targeted by therapeutics; no notable safety concerns)[6][2]
06

Interacting drugs

none known (no approved drugs directly target human olfactory receptors for therapy)[6]
07

Biomarkers

none known (currently not used as a clinical biomarker)

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