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Target intelligence / Profile preview
Olfactory receptor 6C3 (OR6C3)
- Target
- OR6C3
- Molecular classification
- Receptor, G protein-coupled receptor, 7-transmembrane domain protein
01
Overview
Olfactory receptor 6C3 (OR6C3) is a protein encoded by the OR6C3 gene in humans. It belongs to the largest gene family in the genome, the olfactory receptors, which are responsible for the detection of odorant molecules in the nose and the initiation of neuronal signals that result in the perception of smell. Olfactory receptor 6C3 is a member of the G protein-coupled receptor (GPCR) family, and typical of such receptors, has a 7-transmembrane domain structure. These receptors recognize specific odorants and mediate signal transduction via G proteins, though the specific odorant ligands and physiological roles for OR6C3 remain undefined. There are no known endogenous or exogenous drugs that specifically target this receptor, and it does not serve as a biomarker or therapeutic target in clinical practice.
- Other names
- Olfactory receptor family 6 subfamily C member 3Olfactory receptor 6C3OR6C3OST709HSA8
02
Mechanism of action
Not applicable for drugs, as no drugs are known to modulate this receptor.
03
Biological functions
Olfactory receptor activity (detection of odorant molecules)G protein-mediated signal transduction
04
Disease associations
There is limited evidence directly connecting OR6C3 to major human diseases. Variants in the 1q21 risk region (where this gene family is located) have been associated with visual endophenotypes of autism and schizophrenia, but specific causality for OR6C3 is not well-establishedCataract 21, multiple types (association listed but not fully substantiated)Spinal muscular atrophy, type IV (association listed but not fully substantiated)Most olfactory receptors, including OR6C3, are not currently associated with major disease etiology.
05
Safety considerations
None documented. Olfactory receptors are generally not targeted pharmacologically; therefore, no safety concerns or therapeutic challenges are described for OR6C3
06
Interacting drugs
None documented. There are no approved drugs known to target OR6C3 specifically
07
Biomarkers
None established. OR6C3 is not used as a biomarker for patient selection or monitoring
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