Target intelligence / Profile preview

Olfactory receptor 9A2 (OR9A2)

Target
OR9A2
Molecular classification
G protein-coupled receptor (GPCR), Receptor, Olfactory receptor
01

Overview

Olfactory receptor 9A2 is part of the human olfactory receptor gene family, the largest family of G protein-coupled receptors in the genome. These receptors are expressed in the olfactory epithelium of the nose, where they interact with odorant molecules to initiate signal transduction through G proteins, resulting in neuronal signaling and the perception of smell. Olfactory receptors share the canonical seven-transmembrane domain architecture common to GPCRs. While typically associated with the sense of smell, some olfactory receptors may play wider roles in non-olfactory tissues, although OR9A2’s precise functions outside the olfactory system have not yet been established. No current pharmacological agents or disease biomarkers target OR9A2, nor is it associated with any major pathology or safety issues

Other names
OR9A2Olfactory receptor family 9 subfamily A member 2Olfactory receptor OR7-2olfactory receptor 9A2olfactory receptor OR7-2
02

Mechanism of action

For odorant molecules, the mechanism is ligand binding (odorant) causing activation of G protein-coupled signaling and subsequent neuronal signaling that leads to olfactory perception\nNo drug mechanisms of action are known, as no drugs act on OR9A2

03

Biological functions

Signal transduction (odorant recognition and GPCR-mediated neuronal signal generation)Chemosensory transduction (detection of odorant molecules in the nose)Possibly neurotransmission in non-olfactory tissues, pending further research
04

Disease associations

No definitive disease associations are established for OR9A2 at this time ("Other")
05

Safety considerations

No notable safety concerns or therapeutic challenges described, as olfactory receptors (including OR9A2) are not current therapeutic targets
06

Interacting drugs

No known drugs selectively interact with OR9A2.

1 more in the full profile.

07

Biomarkers

No established biomarkers for patient selection or efficacy monitoring

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