Olfactory receptor family 1 subfamily A member 1 (OR1A1)

Olfactory receptor family 1 subfamily A member 1 (OR1A1) is a member of the largest transmembrane protein family in the human genome—the olfactory receptors—which are part of the class A (rhodopsin-like) G protein-coupled receptors (GPCRs). OR1A1 recognizes a range of odorant molecules, including various aliphatic alcohols, aldehydes, and ketones, triggering signal transduction cascades that lead to perception of smell. It has a seven-transmembrane domain structure and functions in the nose, with broad ligand specificity for molecules such as citronellal, octanal, heptanal, dihydrojasmone, nonanal, musks, and thiols. It is not associated with direct therapeutic applications but is studied for understanding GPCR function and olfactory binding mechanisms[1][2][3][4].

Other names

OR1A1Olfactory receptor 1A1OR17-7Olfactory receptor 17-7Olfactory receptor OR17-11Olfactory receptor family 1 subfamily A member 1

Agonists (odorants) bind to receptor, activate G protein-coupled signaling, leading to cAMP increase and neuron depolarization