Olfactory receptor family 1 subfamily B member 1 (OR1B1)

Olfactory receptor family 1 subfamily B member 1 (OR1B1) is a member of the olfactory receptor family, which forms the largest group of G protein-coupled receptors (GPCRs) in the human genome[1][8]. These receptors are responsible for detecting odorant molecules in the nose and triggering neuronal responses that result in the perception of smell[1][8]. OR1B1 shares a typical 7-transmembrane domain structure with many neurotransmitter and hormone receptors and mediates G protein–dependent signal transduction upon odorant binding[1][5][7]. The OR1B1 gene can be a segregating pseudogene, meaning that in some people it encodes a functional receptor, while in others the allele is likely nonfunctional[1]. As of 2024, OR1B1 is classified as an orphan receptor, with no identified specific ligands or drugs known to interact with it[8]. There are no established roles for OR1B1 in human disease or as a therapeutic target beyond olfactory physiology, though a single genetic association with Arrhythmogenic Right Ventricular Cardiomyopathy has been reported without strong evidence of causality[1].

Other names

Olfactory receptor 1B1OR1B1OR9-BOlfactory receptor 9-BOlfactory receptor OR9-26OR9-26Olfactory receptor, family 1, subfamily B, member 1