Olfactory receptor family 1 subfamily C member 1 (OR1C1)

Olfactory receptor family 1 subfamily C member 1 (OR1C1) is a member of the olfactory receptor family, which consists of G protein-coupled receptors (GPCRs) responsible for the recognition and transduction of odorant signals in the nose[1][7]. These receptors have a characteristic 7-transmembrane domain structure that is shared with many other neurotransmitter and hormone receptors[1][3][4]. OR1C1 is encoded by a single coding-exon gene, which is typical for olfactory receptors. Upon binding to specific odorant molecules, OR1C1 initiates a neuronal response that results in the perception of smell[1][7]. The olfactory receptor gene family is the largest in the human genome and is crucial for detecting a wide variety of odorant chemicals. OR1C1 is expressed primarily in the olfactory epithelium but, like other olfactory receptors, may also be present in other tissues with potential non-olfactory functions, e.g., possible expression in spermatozoa involved in chemotaxis and chemokinesis, although the direct function of OR1C1 outside the olfactory system is not well characterized[2]. Olfactory receptors, including OR1C1, have been implicated in the olfactory signaling pathway and may be associated with certain diseases, such as autism spectrum disorder[1]. There are no known therapeutic drugs targeting OR1C1 and its direct mechanism-of-action for pharmacological agents has not been established as of current knowledge[1][7].

Other names

Olfactory receptor 1C1TPCR27HSTPCR27Olfactory receptor OR1-42Olfactory receptor TPCR27OR1-42OR1.5.10ORL211OR1C1