Olfactory receptor family 1 subfamily E member 3 (OR1E3)

Olfactory receptor family 1 subfamily E member 3 (OR1E3) is classified as a pseudogene in the human genome[5][7]. It belongs to the olfactory receptor (OR) superfamily, which is part of the large and highly diverse family of G protein-coupled receptors (GPCRs) responsible for recognizing odorant molecules and initiating signal transduction that allows for the perception of smell[5][7]. OR1E3, despite occasionally being referred to as a receptor, does not produce a functional protein in most humans and is considered non-functional, although rare reports suggest certain pseudogenes may regain function under special conditions[4]. Most scientific databases (GeneCards, NCBI, HGNC) classify OR1E3 as a "gene/pseudogene" and assign it no defined role as a therapeutic target or disease mediator[2][6][7]. Functional olfactory receptors do play key roles in olfaction and GPCR signaling, but OR1E3 specifically is not associated with drug interactions, biomarker utility, or therapeutic safety concerns. Key considerations: - The primary issue with this target is that it is a pseudogene, not capable of producing a functional protein in most individuals[5][7]. - It is not considered a druggable or therapeutic target. - The multiple names and aliases largely refer to the same non-functional genomic locus. - Researchers should exercise caution to avoid conflating OR1E3 with functional olfactory receptors such as OR51E2, which is a validated and structurally characterized human odorant GPCR[1][3]. Summary: OR1E3 is a non-functional olfactory receptor pseudogene; it should not be considered a therapeutic target, and the abundance of aliases may cause confusion. If a functional human olfactory receptor target is required, do not use OR1E3.

Other names

Olfactory receptor 1E3OR1E3OR1E3POR17-210Olfactory receptor 17-210Olfactory receptor OR17-7HsOR17.1.3PORL3749

Not applicable (no drugs act on OR1E3)