Olfactory receptor family 1 subfamily L member 6 (OR1L6)

Olfactory receptor family 1 subfamily L member 6 (OR1L6) is a protein coding gene that encodes an olfactory receptor expressed in the nasal epithelium. Like other olfactory receptors, OR1L6 is a member of the G protein-coupled receptor (GPCR) superfamily and is characterized by a seven-transmembrane domain structure essential for recognizing odorant molecules and mediating G protein-dependent signal transduction, ultimately leading to the perception of smell[3][5][7]. Olfactory receptors constitute the largest gene family in the human genome, and the nomenclature for these genes is organism-specific[3][5]. OR1L6 does not currently have established roles as a clinical biomarker or therapeutic target; no drugs targeting this receptor are approved or in clinical use[5][7]. The biological function is limited to enabling olfaction via primary signal transduction mechanisms in sensory neurons[5][7]. Reports of disease associations are limited, with rare instances such as Alternating Hemiplegia Of Childhood noted in genomic data[5]. OR1L6 and its related receptors are frequently studied for their fundamental biological roles, molecular structure, and function, particularly in understanding the mechanisms of odorant molecule recognition and GPCR signal transduction[1][7].

Other names

Olfactory receptor 1L6OR1L6OR1L7Olfactory receptor 1L7Olfactory receptor OR9-30HG16OR1K1Olfactory receptor, family 1, subfamily L, member 7

Activation via interaction with odorant molecules in the nose; Signal transduction mediated by G protein coupling